|
Sign In to gain access to subscriptions and/or personal tools.
|
First published on December 26, 2007, doi:10.1177/1076029607304750
Clinical and Applied Thrombosis/Hemostasis 2008;14:369.
A more recent version of this article appeared on July 1, 2008
© 2007 SAGE Publications
Severe Arterial Thrombophilia Associated With a Homozygous MTHFR Gene Mutation (A1298C) in a Young Man With Klinefelter Syndrome
Mustafa Ozbek, MD,
M. Akif Ozturk, MD*,
Kemal Ureten, MD,
Ozcan Ceneli, MD,
Mehmet Erdogan, MD,
and
Ibrahim C. Haznedaroglu, MD
Saglik Bakanligi Eltik Ihtisas Hastanesi
* To whom correspondence should be addressed. E-mail: makifozturk{at}yahoo.com.
 |
Abstract |
|---|
Klinefelter syndrome (KS) is the most common sex chromosome disorder in men. It may be associated with an increased risk for venous thrombosis and thromboembolism, which is partially explained by hypofibrinolysis due to androgen deficiency. Additional genetic or acquired thrombophilic states have been shown in KS patients complicated with venous thrombosis as isolated case reports. Arterial thrombotic events had not been previously reported in KS. In this study, a young man with KS who developed acute arterial thrombosis during testosterone replacement therapy is presented. He was homozygous for the A1298C mutation of the methylenetetrahydrofolate reductase (MTHFR) gene.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
|
