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First published on December 26, 2007, doi:10.1177/1076029607306397

Clinical and Applied Thrombosis/Hemostasis 2008;14:346.

A more recent version of this article appeared on July 1, 2008
 © 2007 SAGE Publications

Article

Platelet Aggregation and Activation in Thalassemia Major Patients in Indonesia

Rahajuningsih Setiabudy, MD, DSc*, Pustika Amalia Wahidiyat, MD, and Lyana Setiawan, MD

Ciptomangunkusumo National General Hospital, University of Indonesia

* To whom correspondence should be addressed. E-mail: setiabudy{at}cbn.net.id.


  Abstract
Thromboembolic events and hypercoagulable state have been reported in patients with thalassemia. As platelets play an important role in the pathogenesis of thrombosis, the authors aimed to find the pattern of changes in platelet count, function and activation, and evidence of coagulation activation in patients with thalassemia major in Indonesia. A total of 31 patients with splenectomized and 35 patients with nonsplenectomized thalassemia major were enrolled in this study. Platelet count, platelet aggregation, {beta}-thromboglobulin, and D-dimer levels were measured. All measured parameters were significantly higher in splenectomized than in nonsplenectomized patients. {beta}-thromboglobulin level was increased, but D-dimer level was within normal range. The authors concluded that there was an increase in platelet activation in patients with {beta}-thalassemia major. Platelet activation was higher in splenectomized than in non-splenectomized patients.


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