|
Sign In to gain access to subscriptions and/or personal tools.
|
First published on December 26, 2007, doi:10.1177/1076029607309176
Clinical and Applied Thrombosis/Hemostasis 2008;14:279.
A more recent version of this article appeared on July 1, 2008
© 2007 SAGE Publications
Elevated Levels of Prothrombin Fragment 1 + 2 Indicate High Risk of Thrombosis
Satoshi Ota, MD, PhD,
Hideo Wada, MD, PhD*,
Yasunori Abe,
Eri Yamada,
Akane Sakaguchi,
Junji Nishioka, PhD,
Tsuyoshi Hatada, MD, PhD,
Ken Ishikura, MD, PhD,
Norikazu Yamada, MD, PhD,
Akihiro Sudo, MD, PhD,
Atsumasa Uchida, MD, PhD,
and
Tsutomu Nobori, MD, PhD
Mie University Graduate School of Medicine
* To whom correspondence should be addressed. E-mail: wadahide{at}clin.medic.mie-u.ac.jp.
 |
Abstract |
|---|
Prothrombin fragment 1 + 2 (F1 + 2) is considered to be useful for diagnosis of thrombosis. However, the evidence for a diagnosis of thrombosis by F1+ 2 is still not well established. The plasma concentrations of F1 + 2, soluble fibrin, D-dimer, and thrombin-antithrombin complex were measured in 694 patients suspected of having thrombosis and then were correlated with thrombosis. Plasma concentrations of F1 + 2, soluble fibrin, D-dimer, and thrombin-antithrombin complex were significantly higher in patients with thrombosis, compared with patients without thrombosis. When cutoff values of more than 300 pmol/L for F1 + 2 were used for the diagnosis, more than 50% of the patients were thus found to have thrombosis. The findings showed that F1 + 2, soluble fibrin, D-dimer, and thrombin-antithrombin complex have similar diagnostic ability. The plasma concentration of F1 + 2 closely was well correlated with thrombin-antithrombin complex, soluble fibrin, and D-dimer. Finally, F1 + 2 is one of the most useful parameters for the diagnosis of thrombosis.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
|
