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First published on December 26, 2007
Clinical and Applied Thrombosis/Hemostasis 2007, doi:10.1177/1076029607310217
© 2007 SAGE Publications

Article

Thrombophilia in Human Immunodeficiency Virus–Infected Patients With Osteonecrosis: Is There a Real Connection? The First Case-Control Study

Gabriela de Larrañaga, PhD*, Edgardo Bottaro, MD, Marta Martinuzzo, PhD, Raúl Figueroa, MD, María Luisa Iglesias Varela, PhD, Silvia Perés Wingeyer, PhD, Ricardo Forastiero, PhD, Yolanda Adamczuk, PhD, Marcelo Corti, MD, Liliana Puga, MD, and Jorge Benetucci, MD

* To whom correspondence should be addressed. E-mail: gabriela{at}hemostasia.com.ar.


  Abstract
Several reports have described an increased incidence of osteonecrosis in human immunodeficiency virus–infected patients (HIV+), but the cause has not been established. The association between thrombophilia and osteonecrosis in HIV+ was studied. A case-control study in HIV+, 19 cases and 38 controls, was designed. Magnetic resonance imaging was made in both groups to confirm or exclude hip osteonecrosis. The extensive tests of thrombophilia were measured, and the clinical data were recorded, nadir of CD4+ cell count and well-known risk factors for osteonecrosis. Thrombophilia has been frequently found both in patients with and without osteonecrosis (thrombophilia, 68.4% vs 60.5%), but no specific thrombophilia tests were significantly associated with osteonecrosis. A low nadir of CD4+(<60 cells/µL) and corticoid use were significantly (P < .05) associated with osteonecrosis. In multivariate analysis, only nadir of CD4+ <60 cells/µL remained a predictor of osteonecrosis (odds ratio = 7.33; 95% confidence interval, 1.8029.82, P = .005). Thrombophilia might have a limited role in the development of osteonecrosis in HIV+. Nadir of CD4+ <60 cells/µL and corticoid use were main factors.


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