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PAI-1 and D-Dimer in Type 2 Diabetic Women With Asymptomatic Macrovascular Disease Assessed by Carotid Doppler
Anna Letícia Soares*,
Pedro Wesley Rosário,
Michelle Aparecida Ribeiro Borges,
Marinez Oliveira Sousa,
Ana Paula Salles Moura Fernandes,
and
Maria das Graças Carvalho
* To whom correspondence should be addressed. E-mail: alsoares{at}ufmg.br.
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Abstract |
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Asymptomatic diabetic patients with different degrees of macrovascular complications can present different hemostatic changes. At this study, plasminogen activator inhibitor-1 (PAI-1) and <scp>d</scp>-dimer were evaluated in 12 women without diabetes and 64 type 2 diabetic women. All patients were classified into 3 different categories according to the carotid intima-media thickness (IMT) assessed by Doppler: 25 with <1 mm (normal), 15 with >1 mm and without plaque (intermediate), and 24 with stenosis lower than 50% of the vessel lumen (plaque). The results showed increased plasma <scp>d</scp>-dimer in type 2 diabetic women with carotid plaque when compared to the other groups. High levels of PAI-1 were observed in all the 3 groups of diabetic women when compared to women without diabetes. Our results suggest that high levels of PAI-1 in type 2 diabetic women are only associated with diabetes and are not associated with macrovascular progression; however, it seems that <scp>d</scp>-dimer plasma levels are associated with carotid plaque.
First published on October 13, 2009
Clinical and Applied Thrombosis/Hemostasis 2009, doi:10.1177/1076029609334626
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