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Low Dose of Argatroban Saline Flushes Anticoagulation in Hemodialysis Patients With High Risk of Bleeding

^* To whom correspondence should be addressed. E-mail: zpning632xy{at}medmail.com.

	Abstract

Background: Anticoagulation in hemodialysis (HD) patients with high risk of bleeding is still an intractable problem. Method: A total of 80 HD sessions with high risk of bleeding were completed with either heparin-free (HF) or low dose of argatroban saline flushes (LASF) anticoagulation. Clinical clot formation in the pipeline and dialyzer was inspected to evaluate the local anticoagulation efficiency; prothrombin time (PT), activated partial thromboplastin time (aPTT), and <scp>d</scp>-dimer were tested to investigate the influence on the whole body coagulation system; urea reduction ratio (URR) and Kt/V were used to evaluate the efficiency of dialysis. Results: Comparing with HF, LASF showed a satisfactory efficiency in reducing the clot formation and the URR and Kt/V of it were also higher. Conclusions: Low dose of argatroban saline flushes is a feasible and safe alternative anticoagulation protocol in HD patients with high risk of bleeding.

First published on October 14, 2009
Clinical and Applied Thrombosis/Hemostasis 2009, doi:10.1177/1076029609334628


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