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Association Between ApoE4 Allele and Deep Venous Thrombosis: A Pilot Study
Nurkay Katrancioglu, Asist. Prof.*,
Sinasi Manduz,,
Filiz Ozen,
Mehmet Birhan Yilmaz,
Erhan Atahan,
Ozturk Ozdemir,
and
Ocal Berkan
* To whom correspondence should be addressed. E-mail: nurkay{at}gmail.com.
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Abstract |
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Introduction: Deep vein thrombosis (DVT) is a multifactorial disease with genetic and acquired risk factors playing in concert in its pathogenesis. ApoE gene polymorphisms seem to have some impact among patients with cardiovascular disease; however, association between DVT and ApoE gene polymorphism has not been evaluated. Materials and Methods: We aimed to search the relative frequencies ApoE alleles among patients with DVT and healthy participants. We enrolled 59 consecutive patients with DVT and 59 age- and sex-matched healthy controls. Results: In the DVT group, E3/E4 gene polymorphism was detected in 20 patients (33.9%), in the control group E3/E4 polymorphism was detected in six patients (10.2%; P = .002). In the multivariable regression analysis, E3/E4 was independently associated with 1.31-fold increased risk of DVT (odds ratio [OR] 1.31; 95% confidence interval [CI], 1.30-10.48). Conclusion: It seems there is a relationship between ApoE3/E4 gene polymorphism and DVT in the Turkish population. However, this pilot study should be supported with large-scale studies.
First published on October 13, 2009
Clinical and Applied Thrombosis/Hemostasis 2009, doi:10.1177/1076029609348646
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