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Diabetic Ulcers: Microcirculatory Improvement and Faster Healing With Pycnogenol

M. R. Cesarone, MD

B. M. Errichi, MD

A. Ledda, MD

A. Di Renzo, MD

S. Stuard, MD

M. Dugall, MD

L. Pellegrini, MD

G. Gizzi, MD

Irvine2 Vasc Lab, Department of Biomedical Sciences, Chieti-pescara University and San Valentino Vascular Screening Project, Westfälische Wilhelms-Universität Münster, Germany (PR)

P. Rohdewald, PhD

Institute Pharmaceutical Chemistry, Westfälische Wilhelms-Universität Münster, Germany

E. Ippolito, MD

A. Ricci, MD

M. Cacchio, MD

G. Cipollone, MD

I. Ruffini, MD

F. Fano, BA

M. Hosoi, BA

Irvine2 Vasc Lab, Department of Biomedical Sciences, Chieti-pescara University and San Valentino Vascular Screening Project, Westfälische Wilhelms-Universität Münster, Germany (PR)

Diabetic microangiopathy leads to lower limb ulcers that are very slow to heal. Pycnogenol was evaluated on diabetic ulcers in a controlled trial. Ulcer medications were used in 4 groups (30 patients): (1) systemic Pycnogenol and local application; (2) local Pycnogenol only; (3) oral Pycnogenol; and (4) medications only (control group). Ulcerated areas and symptom scores were more reduced with the combined oral and local treatment (P < .05). Oral and local treatment were less effective, but still improved compared with the controls. Combined treatment produced 89% complete healing at 6 weeks versus 84% with local treatment and 85% with oral treatment; healing in controls was 61%. The combined treatment group and oral only group had better microcirculation after the combined treatment. Combined local and systemic application of Pycnogenol may offer a new treatment of diabetic ulcers. Local treatment also speeds ulcer healing.

Key Words: diabetic microangiopathy • Pycnogenol • capillary filtration

Clinical and Applied Thrombosis/Hemostasis, Vol. 12, No. 3, 318-323 (2006)
DOI: 10.1177/1076029606290133


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