This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Web of Science (1) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Meyer, O. Articles by Salama, A. Search for Related Content PubMed PubMed Citation Articles by Meyer, O. Articles by Salama, A. Pubmed/NCBI databases Substance via MeSH Medline Plus Health Information Blood Thinners Platelet Disorders Hazardous Substances DB HEPARIN Social Bookmarking                         What's this?

Report of a Patient With Heparin-induced Thrombocytopenia Type II Associated With IgA Antibodies Only

T. Aslan, MD

Institut für Transfusionsmedizin, Charité, Universitätsmedizin Berlin, Germany

A. Koster, MD

Deutsches Herzzentrum Berlin, Germany

H. Kiesewetter, MD

A. Salama, MD

Institut für Transfusionsmedizin, Charité, Universitätsmedizin Berlin, Germany

Heparin-induced thrombocytopenia type II (HIT II) is usually mediated by immunoglobulin G (IgG) antibodies that lead to platelet activation via the FcIIA-receptor. Here we describe a patient who developed HIT II after aortocoronary bypass surgery. His serum contained an antibody that was detectable by the heparin-induced platelet activation assay (HIPA) and by the ID-HPF4 particle agglutination assay. The flow cytometric analysis showed that the antibody was of the IgA class.

Key Words: Heparin-induced thrombocytopenia • Heparin/PF4-antibodies • Immunoassay • Platelet activation assay

Clinical and Applied Thrombosis/Hemostasis, Vol. 12, No. 3, 373-375 (2006)
DOI: 10.1177/1076029606291400


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?