SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Clinical and Applied Thrombosis/Hemostasis
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Web of Science (2)
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Alacacioglu, I.
Right arrow Articles by Undar, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Alacacioglu, I.
Right arrow Articles by Undar, B.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Increased Concentration of Soluble CD40 Ligand in Preeclampsia

Inci Alacacioglu, MD

Department of Haematology, Dokuz Eylul University Faculty of Medicine, Turkey, inci074{at}yahoo.com

Mehmet Ali Ozcan, MD

Department of Haematology, Dokuz Eylul University Faculty of Medicine, Turkey

Ozden Piskin, MD

Department of Haematology, Dokuz Eylul University Faculty of Medicine, Turkey

Faize Yuksel, MSci

Department of Haematology, Dokuz Eylul University Faculty of Medicine, Turkey

Ahmet Alacacioglu, MD

Department of Haematology, Dokuz Eylul University Faculty of Medicine, Turkey

Fatih Demirkan, MD

Department of Haematology, Dokuz Eylul University Faculty of Medicine, Turkey

Hayri Guner Ozsan, MD

Department of Haematology, Dokuz Eylul University Faculty of Medicine, Turkey

Mesut Polat, MD

Maternity Hospital of Tepecik, Izmir, Turkey

Yigit Ozgenc, MD

Maternity Hospital of Tepecik, Izmir, Turkey

Bulent Undar, MD

Department of Haematology, Dokuz Eylul University Faculty of Medicine

Preeclampsia has been associated with increased platelet activation detected before disease onset. Platelets are involved in hemostasis and also directly initiate an inflammatory response of the vessel wall. Inappropriate activation of platelets may be involved in pathogenesis in preeclampsia by promoting coagulation and thrombosis, and also as a mediator of inflammation. Platelets may release inflammatory mediators such as soluble CD40 ligand. The plasma level of soluble CD40 ligand was investigated during preeclamptic (n =20) and normal pregnancies (n = 20) to emphasize inflammatory response in preeclampsia. The mean soluble CD40 ligand levels were 1.08 ± 0.43 ng/mL in patients with preeclampsia and 0.76 ± 0.24 ng/mL in healthy pregnant women, which was statistically significant (P = .01). To clarify whether inflammation may cause inappropriate endothelial cell activation or inappropriate endothelial cell activation may start this inflammatory response, future studies are needed in a larger study population.

Key Words: preeclampsia • inflammation • soluble CD40 ligand

Clinical and Applied Thrombosis/Hemostasis, Vol. 13, No. 2, 201-205 (2007)
DOI: 10.1177/1076029606299076
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement