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Recurrent Abortions in Asian Indians: No Role of Factor V Leiden Hong Kong/Cambridge Mutation and MTHFR Polymorphism

Department of Haematology, AMS, Indraprastha University Delhi, India

Priya Choudhry, BTech

Department of Biotechnology, Indraprastha University Delhi, India

Anuradha Mittal, BTech

Department of Haematology, AMS, Indraprastha University Delhi, India, Department of Biotechnology, Indraprastha University Delhi, India

Arvind Meena, MSc

Department of Haematology, AMS, Indraprastha University Delhi, India

Ravi Ranjan, MSc

Department of Haematology, AMS, Indraprastha University Delhi, India

V.P. Choudhry, MD

Department of Haematology, AMS, Indraprastha University Delhi, India

Renu Saxena, MD

Department of Haematology, AMS, Indraprastha University Delhi, India, renusax{at}hotmail.com

Recurrent fetal loss is a frequent health problem. Data accumulated over the past few years have suggested a possible correlation between thrombophilia and fetal loss. Although a clear association has been established between fetal loss and certain thrombophilic states, such as antiphospholipid antibody syndromes, antithrombin deficiency, and combined defects, reports on the prevalence of inherited prothrombotic defects such as factor V Leiden mutation and methylene tetrahydrofolate reductase C677T polymorphism in fetal loss are contradictory. The prevalence of these 2 mutations in Asian Indians with recurrent fetal loss has not yet been studied. In light of this, the present study looked at the prevalence of these mutations in 85 patients with spontaneous recurrent abortion and 31 controls. The authors did not find any significant role of these mutations in the development of recurrent abortion.

Key Words: recurrent fetal loss • FV Leiden • thrombophilia • MTHFR C677T polymorphism • maternal blood

This version was published on January 1, 2008

Clinical and Applied Thrombosis/Hemostasis, Vol. 14, No. 1, 102-104 (2008)
DOI: 10.1177/1076029607303774


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