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Mean Maternal Second-Trimester Hemoglobin Concentration and Outcome of Pregnancy: A Population-Based Study

Department of Obstetrics and Gynecology; Health and Care Center Ruesselsheim, Ruesselsheim, Germany, G-F.von.Tempelhoff{at}gmx.de

Lothar Heilmann, MD

Department of Obstetrics and Gynecology; Health and Care Center Ruesselsheim, Ruesselsheim, Germany

Lothar Rudig, MD

Department of Obstetrics and Gynecology; Health and Care Center Ruesselsheim, Ruesselsheim, Germany

Kunhard Pollow, PhD, MD

Institute for Experimental Endocrinology, University of Mainz, Mainz, Germany

Gerhard Hommel, PhD

Institute for Medical Biometrics, Epidemiology and Informatic; University of Mainz, Mainz, Germany

Jürgen Koscielny, MD

Institute for Transfusion Medicine, Charité Humboldt-University, Berlin, Germany

Both anemia and the lack of physiological maternal plasma volume expansion during the second trimester are associated with higher maternal morbidity and poor fetal outcome. Mean hemoglobin levels between the 14th and 30th gestational weeks were calculated in 4985 consecutive pregnant women and were correlated with outcome data of pregnancy. It was found that 9.4% of participants (n = 3959) had normal pregnancy outcome. Mean maternal hemoglobin levels were significantly lower in women with a normal pregnancy (11.96 ± 0.94 g/dL) compared with women who had adverse outcome events (preeclampsia, n = 423, 12.5 ± 1.0 g/dL, P < .0001; early birth, n = 464, 12.2 ± 1.01 g/dL, P < .0001; low birth weight newborn, n = 473, 12.2 ± 1.10 g/dL, P < .0001; intrauterine growth retardation, n = 250, 12.2 ± 1.0 g/dL, P < .0001). The risk for any adverse outcome event was lowest with a mean hemoglobin between 11.0 and 12.0 g/dL (odds ratio, 0.625; 95% confidence interval, 0.43-0.89) and highest between 13.0 and 15.0 g/dL (odds ratio, 2.24; 95% confidence interval, 1.54-3.31). In this population-based study from a community in Western Germany, impaired plasma volume expansion was an independent risk factor for the development of an adverse outcome of pregnancy.

Key Words: plasma volume • hemoglobin • preeclampsia • low birth weight • preterm delivery • intrauterine growth retardation • hemodilution

Clinical and Applied Thrombosis/Hemostasis, Vol. 14, No. 1, 19-28 (2008)
DOI: 10.1177/1076029607304748


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