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Clinical and Applied Thrombosis/Hemostasis
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Correction of the Bleeding Time With Lyophilized Platelet Infusions in Dogs on Cardiopulmonary Bypass

Arthur P. Bode, PhD

Department of Pathology and Laboratory Medicine, East Carolina University School of Medicine, Greenville, North Carolina, bodea{at}ecu.edu

Robert M. Lust, PhD

Department of Physiology East Carolina University School of Medicine, Greenville, North Carolina

Marjorie S. Read, PhD

Department of Pathology The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

Thomas H. Fischer, PhD

Department of Pathology The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

Lyophilized canine platelets were infused in a single large bolus dose into splenectomized dogs after 2 hours' perfusion on cardiopulmonary bypass to test their possible efficacy in restoring hemostasis after compromise of platelet function. The vessel bleeding time (VBT) was monitored by venipuncture of the exposed jugular vein. During cardiopulmonary bypass, platelet counts fell quickly and the VBTs became prolonged over baseline. Infusion of lyophilized platelets reconstituted in normal saline occurred just before or immediately after weaning from the cardiopulmonary bypass pump. The results showed consistent and persistent lowering of the VBTs by the infused lyophilized platelets. Controls showed continuously prolonged VBTs. The weighted average VBT in infused subjects was significantly lower than the average in controls: 3 minutes 10 seconds versus 6 minutes 59 seconds, respectively (t test, P = .01). These results in this setting indicate the possible effectiveness of similar human lyophilized platelet preparations in reducing postoperative bleeding in open heart surgery.

Key Words: platelets • freeze-dried • cardiopulmonary bypass • bleeding time • hemorrhage

This version was published on January 1, 2008

Clinical and Applied Thrombosis/Hemostasis, Vol. 14, No. 1, 38-54 (2008)
DOI: 10.1177/1076029607304746
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