This Article Full Text (PDF) All Versions of this Article: 1076029607309173v1 14/3/360    most recent References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Google Scholar Articles by Sucker, C. Articles by Stockschlader, M. PubMed PubMed Citation Articles by Sucker, C. Articles by Stockschlader, M. Social Bookmarking                   What's this?

Fatal Bleeding Due to a Heparin-Like Anticoagulant in a 37-Year-Old Woman Suffering From Systemic Mastocytosis

Departments of Hemostasis and Transfusion Medicine, Heinrich Heine University Medical Center

Georg Mansmann, MD

Department of Cardiology, Pneumology and Angiology, Heinrich Heine University Medical Center

Stefan Steiner, MD

Department of Endocrinology, Diabetes and Rheumatology, Heinrich Heine University Medical Center

Norbert Gattermann, MD, PhD

Hematology, Oncology and Clinical Immunology Heinrich Heine University Medical Center, Düsseldorf

Anette Schmitt-Graeff, MD, PhD

Department of Pathology, University of Freiburg Germany

Robert Loncar, MD

Departments of Hemostasis and Transfusion Medicine, Heinrich Heine University Medical Center

Rudiger E. Scharf, MD, PhD

Departments of Hemostasis and Transfusion Medicine, Heinrich Heine University Medical Center

Marcus Stockschlader, MD

Departments of Hemostasis and Transfusion Medicine, Heinrich Heine University Medical Center, stockschlaeder{at}med.uni-duesseldorf.de

A 37-year-old female patient with systemic mastocytosis who was admitted with severe unexplained bleeding symptoms is studied. Laboratory procedures established the diagnosis of a patient-derived—heparin-like anticoagulant as a very rare hemostatic abnormality predisposing to bleeding. The patient died from refractory disease despite therapy with protamine, initiation of chemotherapy, and supportive measures. The case illustrates the clinical presentation and diagnosis of heparin-like anticoagulants. Etiology, pathophysiology, and therapeutic options are discussed.

Key Words: heparin-like anticoagulants • systemic mastocytosis • fatal bleeding

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?