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Clinical and Applied Thrombosis/Hemostasis
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A Functional Ser413/Ser413 PAI-2 Polymorphism Is Associated With Susceptibility and Damage Index Score in Systemic Lupus Erythematosus

Claudia A. Palafox-Sánchez, MD, MSc

Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (RSME), Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, University of Guadalajara, Jalisco

Mónica Vázquez-Del Mercado, MD, PhD

Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (RSME), Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, University of Guadalajara, Jalisco

Gerardo Orozco-Barocio, MD

Departamento de Inmunología y Reumatología del Hospital General de Occidente, Secretaría de Salud Jalisco, Zapopan, Jalisco

Ignacio García-De la Torre, MD

Departamento de Inmunología y Reumatología del Hospital General de Occidente, Secretaría de Salud Jalisco, Zapopan, Jalisco

Norma Torres-Carrillo, BSc, MSc

Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (RSME), Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, University of Guadalajara, Jalisco

Nora M. Torres-Carrillo, BSc, MSc

Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (RSME), Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, University of Guadalajara, Jalisco

Berenice Illades-Aguiar, PhD

Laboratorio de Biomedicina Molecular, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, Mexico

José F. Muñoz-Valle, PhD

Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético (RSME), Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, University of Guadalajara, Jalisco, biologiamolecular{at}hotmail.com

Systemic lupus erythematosus in some cases is characterized for development of thrombotic events with a significantly increased risk of mortality. The frequencies and clinical associations of Ser413/Cys413 PAI-2 polymorphism in 40 systemic lupus erythematosus, 50 rheumatoid arthritis patients, and 100 healthy subjects were investigated. The Ser413/Ser413 genotype frequency was 53% (lupus), 36% (rheumatoid arthritis), and 35% (healthy subjects). The Ser413 allele was associated with systemic lupus erythematosus (P = .04, odds ratio = 1.76, 95% confidence interval = 1.01-3.06). In all, 4 patient carriers of Ser413/Ser413 genotype, developed thrombotic events. The lupus patients identified with Ser 413/Ser413 genotype showed an increased damage (57%), compared with Ser413/Cys413 and Cys413/Cys413 genotypes, with significant difference (P = .03). These findings suggest an association of Ser413/Ser413 genotype with greater damage index score and Ser413 allele with systemic lupus erythematosus. Besides, PAI-2 polymorphism could be related with thrombotic phenomena in systemic lupus erythematosus

Key Words: plasminogen activator inhibitor 2 • polymorphism • SLE • RA

This version was published on April 1, 2009

Clinical and Applied Thrombosis/Hemostasis, Vol. 15, No. 2, 233-238 (2009)
DOI: 10.1177/1076029607308868
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