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Unexpected Pulseless Disease Associated With Recurrent Venous Thromboembolisms

Department of Internal Medicine and Nephrology, Clinique Sainte-Elisabeth, Namur, johannmorelle{at}hotmail.com

Michel Tintillier, MD

Department of Internal Medicine and Nephrology, Clinique Sainte-Elisabeth, Namur

Jean-Benoit Martinot, MD

Department of Pneumology, Clinique Sainte-Elisabeth, Namur

Stephanie Moortgat, MD

Institute of Pathology and Genetics, Department of Pediatrics, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium

Cedric Hermans, MD, MRCP (UK), PhD

Haemostasis and Thrombosis Unit, Department of Haematology Cliniques Universitaires Saint-Luc, Bruxelles, Belgium

Venous thromboembolic disease is a well-documented complication of Klinefelter’s syndrome, even if mechanisms underlying this prothrombotic state have not been conclusively established. On the contrary, arterial thrombosis is far less frequent, and a case of a patient with Klinefelter’s syndrome presenting with simultaneous venous thrombtoembolic disease and a complete thrombosis of the left subclavian artery is presented. Elevated levels of type 1 plasminogen activator inhibitor, in the absence of other usual thrombophilic abnormalities, raise the question of the role played by this inhibitor of the fibrinolysis in the arterial and venous thromboses presented by this patient.

Key Words: Klinefelter’s syndrome • venous thromboembolic disease • arterial thrombosis • type 1 plasminogen activator inhibitor

This version was published on April 1, 2009

Clinical and Applied Thrombosis/Hemostasis, Vol. 15, No. 2, 239-240 (2009)
DOI: 10.1177/1076029607305782


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