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High Incidence of Factor V Leiden and Prothrombin G20210A in Healthy Southern Italians

Centro Emofilia, Servizio Emostasi e Trombosi Azienda Ospedaliera "Bianchi-Melacrino-Morelli," Reggio Calabria, Italy, sottilotta{at}centroemofilia.it

Corrado Mammì, MD,

Unità Operativa di Genetica Medica Azienda Ospedaliera "Bianchi-Melacrino-Morelli," Reggio Calabria, Italy

Giuseppe Furlò, MD

Servizio di Immunoematologia e Medicina Trasfusionale, Azienda Ospedaliera "Bianchi-Melacrino-Morelli," Reggio Calabria, Italy

Vincenzo Oriana, MD

Centro Emofilia, Servizio Emostasi e Trombosi Azienda Ospedaliera "Bianchi-Melacrino-Morelli," Reggio Calabria, Italy

Caterina Latella, MD

Centro Emofilia, Servizio Emostasi e Trombosi Azienda Ospedaliera "Bianchi-Melacrino-Morelli," Reggio Calabria, Italy

Vincenzo Trapani Lombardo, MD

Centro Emofilia, Servizio Emostasi e Trombosi Azienda Ospedaliera "Bianchi-Melacrino-Morelli," Reggio Calabria, Italy

Factor V Leiden (FVL) and G20210 prothrombin (FII G20210A) mutations are risk factors for thromboembolism. In Europe, FVL is more prevalent in the north (7%) than in the south (3%), whereas FII G20210A is more common in the south (3% to 7%) than in the north (2% to 5%). In Italy, the prevalence is 2% to 3% for both. The aim of this study was to assess if these polymorphisms could be more frequent in the south than in the rest of Italy. In 105 blood donors in southern Italy, the prevalence of FVL and FIIG20210A was 9.5% and 5.7%, respectively. These prevalence data are higher when compared with published data. The results of this study are as high as those observed in Greece and the Middle East. The diffusion of FVL and FII G20210A in the Mediterranean, consequent to Phoenician and Greek colonization, could be a reason for the high prevalence observed.

Key Words: thrombophilia • factor V Leiden • prothrombin G20210

This version was published on June 1, 2009

Clinical and Applied Thrombosis/Hemostasis, Vol. 15, No. 3, 356-359 (2009)
DOI: 10.1177/1076029607310218


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