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Clinical and Applied Thrombosis/Hemostasis
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Prevalence of Thrombophilic Mutations and ACE I/D Polymorphism in Turkish Ischemic Stroke Patients

Gulay Celiker, MD

Department of Neurology Baskent University School of Medicine, Ankara, Turkey

Ufuk Can, MD

Department of Neurology Baskent University School of Medicine, Ankara, Turkey

Hasibe Verdi, MSc

Medical Biology and Genetics Baskent University School of Medicine, Ankara, Turkey

Ayse Canan Yazici, PhD

Biostatistics Baskent University School of Medicine, Ankara, Turkey

Namik Ozbek, MD

Pediatric Hematology Baskent University School of Medicine, Ankara, Turkey

Fatma Belgin Atac, PhD

Medical Biology and Genetics Baskent University School of Medicine, Ankara, Turkey, batac{at}baskent.edu.tr

The aim of this study was to evaluate the prevalence of factor V Leiden (FVL), prothrombin G20210A, methylenetetrahydrofolate reductase (MTHFR) C677T gene mutations, and angiotensin-converting enzyme (ACE) I/D polymorphism in ischemic stroke (IS) patients. A total of 162 Turkish IS patients were included and analyzed according to stroke subtype by the TOAST classification. Their genotype data were compared with those of the control group, representing the healthy population, using the {chi}2 test. The frequency of FVL heterozygocity was 12.3% in this series—higher than that in the normal population (9.8%; statistically insignificant, P = .478). The frequency of the ACE D/D genotype in all stroke patients and those with stroke of undetermined etiology was higher than that in our population (52.5% and 59.2%, respectively, vs 39.3%; statistically significant, P = .034, P = .020). Our results may suggest that ACE D/D genotype is a risk factor for IS, particularly in those with stroke of undetermined etiology in the Turkish population.

Key Words: ischemic stroke • coagulation factors

This version was published on August 1, 2009

Clinical and Applied Thrombosis/Hemostasis, Vol. 15, No. 4, 415-420 (2009)
DOI: 10.1177/1076029608315163
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