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Association of Angiotensin-Converting Enzyme Gene 2350G>A Polymorphism With Myocardial Infarction in a Chinese Population

Department of Cardiology Affiliated Hospital of Soochow University, Suzhou China, Department of Cardiology, First Affiliated Hospital of Soochow University, Suzhou China

Min-Hui Jiang, MD

Department of Cardiology Affiliated Hospital of Soochow University, Suzhou China, zhjhntdx{at}163.com

Mei-Fang Wei, MD

Department of Cardiology Affiliated Hospital of Soochow University, Suzhou China

Zhi-Hua Liu, MD

Department of Cardiology, First Affiliated Hospital of Soochow University, Suzhou China

Wen-Ping Jiang, PhD, MD

Department of Cardiology, First Affiliated Hospital of Soochow University, Suzhou China

Hai-Hua Geng, MD

Department of Cardiology Affiliated Hospital of Soochow University, Suzhou China

Zhi-Chu Cui, MD

Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong

Dong-Lei Zhang, MD

Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong

Jian-Hua Zhu, PhD, MD

Department of Cardiology Affiliated Hospital of Soochow University, Suzhou China

Angiotensin-converting enzyme (ACE) gene 2350G>A polymorphism has the most significant effect on plasma ACE concentrations. But the association between this polymorphism and myocardial infarction (MI) is presently unknown. We carried out a case-control study in the Chinese Han population. ACE2350G>A genotypes of 231 patients with MI and 288 healthy controls were detected by PCR-RFLP. Differences in frequencies of ACE genotypes and alleles and their associations with clinical features were assessed. The distribution of the ACE2350G>A genotypes (GG, GA, and AA) was 20.78%, 51.08%, and 28.14% in the MI group and 31.60%, 46.53%, and 21.87% in controls, respectively (P = .0167).The frequency of the A allele in the MI group was significantly higher than that in controls (53.68% vs 45.14%, P = .0062). The A allele carriers (GA + AA genotypes) had approximately 2-fold increased risk of MI when compared with the GG genotype (odds ratio = 1.76; 95% confidence interval = 1.24-3.52). There were no significant differences among the 3 genotypes in plasma levels of lipids, apolipoproteins, high-sensitivity C-reactive protein, and soluble CD40 ligand in either the MI group or the control group (P > .05). No statistical difference was observed between ACE2350G>A polymorphism and severity of the coronary lesions (P > .05). These results suggest that ACE2350G>A polymorphism is associated with acute MI, and A allele carrier is an independent risk factor for acute MI in the Chinese Han population.

Key Words: angiotensin-converting enzyme • genetic polymorphism • myocardial infarction • Chinese

This version was published on August 1, 2009

Clinical and Applied Thrombosis/Hemostasis, Vol. 15, No. 4, 435-442 (2009)
DOI: 10.1177/1076029608316013


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