This Article Full Text (PDF) All Versions of this Article: 1076029608322173v1 15/4/461    most recent References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Scopus Google Scholar Articles by Gerhardt, A. Articles by Zotz, R. B. PubMed PubMed Citation Articles by Gerhardt, A. Articles by Zotz, R. B. Social Bookmarking                         What's this?

Successful Use of Danaparoid in Two Pregnant Women With Heart Valve Prosthesis and Heparin-Induced Thrombocytopenia Type II (HIT)

Department of Haemostasis and Transfusion Medicine, Heinrich-Heine University Medical Center, Düsseldorf, Germany

Rüdiger E. Scharf, MD, PhD

Department of Haemostasis and Transfusion Medicine, Heinrich-Heine University Medical Center, Düsseldorf, Germany

Rainer B. Zotz, MD

Department of Haemostasis and Transfusion Medicine, Heinrich-Heine University Medical Center, Düsseldorf, Germany, zotz.rainer{at}gmx.de

Anticoagulant therapy with heparin for the prevention of thromboembolism in pregnant women with prosthetic heart valves is associated with an increased risk to the mother and/or the fetus. A life-threatening complication of the therapy with heparin is heparin-induced thrombocytopenia type II (HIT). danaparoid has not yet been reported to be safe and effective for this indication. This study reports on a 26-year-old woman with tricuspidal valve prosthesis and a 37-year-old woman with a St. Jude Medical mitral valve prosthesis who were anticoagulated with danaparoid during pregnancy because of HIT. Anti-Xa levels were between 0.6 and 1.2 IU/mL during pregnancy with target levels of 1.0 IU/mL. Cesarean section was performed at anti-Xa levels of 0.3 and 0.7 IU/mL. One woman developed a placental hematoma at the 32nd week of gestation, which did not increase over the following week. Both patients delivered healthy boys. Heparin-induced thrombocytopenia in pregnant women with prosthetic heart valve can be successfully managed with danaparoid.

Key Words: HIT type II • pregnancy • mechanical heart valve • danaparoid

This version was published on August 1, 2009

Clinical and Applied Thrombosis/Hemostasis, Vol. 15, No. 4, 461-464 (2009)
DOI: 10.1177/1076029608322173


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?