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Arterial Damage, Triglycerides, Apolipoprotein, and Lp-(a) Values in PVD PatientsResearch Center on Vascular Disease, University of Milan, L. Sacco Hospital, Milan, Italy
Research Center on Vascular Disease, University of Milan, L. Sacco Hospital, Milan, Italy
Research Center on Vascular Disease, University of Milan, L. Sacco Hospital, Milan, Italy
Research Center on Vascular Disease, University of Milan, L. Sacco Hospital, Milan, Italy
Research Center on Vascular Disease, University of Milan, L. Sacco Hospital, Milan, Italy The aim of the study was to provide a detailed apolipoproteic profile in stage II peripheral vascular disease (PVD) patients and to ascertain whether lower ankle/ arm pressure index (API) values were associated with a worse profile.
Apolipoproteins of 83 stage II PVD patients (average age 64.7 ± 9.3 years) were selected and compared with those of a group of 44 normal control subjects, similar in terms of age, sex, and smoking and eating habits. Neither PVD patients nor controls had ever received lipid-lowering agents or defined dietary treatment. A diagnosis of PVD was confirmed by an API of <0.85. Arteriopathic patients were also split into two groups, depending on their API values, similar in terms of age, sex and smoking habits: API values of one group (n = 38) were HDL-C and Apo AI were lower (p < 0.01), while TC/ HDL-C ratios, Apo B, and Apo CII were higher (p < 0.01) in PVD patients compared with controls. The comparison between the two PVD groups with different API values showed higher blood TG and VLDL-C values for the patients with lower API values (p < 0.05), indicating a relationship between hypertriglyceridemia and greater arterial damage. Key Words: Peripheral arterial occlusive disease-Triglyceride-Lipoprotein a.
Clinical and Applied Thrombosis/Hemostasis, Vol. 3, No. 2,
104-109 (1997) |
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0.6, those of the other group (n = 45) were <0.6. The following biohumoral parameters were considered: fasting glycemia, total cholesterol, triglycerides (TGs); high-density lipoprotein cholesterol (HDL-C); low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), total cholesterol (TC)/HDL-C (TC/ HDL-C), Apoproteins (Apos) AI, AII, B, CII, CIII, and E; and lipoprotein a [Lp(a)].