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Clinical and Applied Thrombosis/Hemostasis
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Evans's Syndrome with Positive Lupus Anticoagulant and Antiphospholipid-Protein Antibodies

Jacek Musial, M.D., Ph.D.

Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland

Marzena Frolow, M.D.

Department of Hematology, Jagiellonian University School of Medicine, Krakow, Poland

Aleksander B. Skotnicki, M.D., Ph.D.

Department of Hematology, Jagiellonian University School of Medicine, Krakow, Poland

Milosz Jankowski, M.D.

Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland

Jakub Swadzba, M.D.

Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland

We report a case of a 34-year-old Caucasian man with Evans's syndrome, first manifested in childhood as autoimmune thrombocytopenia. Besides anti-erythrocyte antibodies and platelet-associated immunoglobulins, this patient's serum showed also the presence of antiphospholipid-protein antibodies detected by coagulometric (lupus anticoagulant) as well as immunoenzymatic methods (anticardiolipin, antiprothrombin, and anti-ß2-glycoprotein I antibodies). Over 25 years of clinical observation the patient never experienced any thromboembolic events. We suggest that in the pathogenesis of Evans's syndrome and related disorders a major role is played by an autoimmune reaction with a predilection to various cell phospholipid-containing membrane structures, possibly damaged by a yet unknown primary insult. The significance of these various antiphospholipid-protein antibodies as predictors of thromboembolic complications in such patients remains, however, to be established. Key Words: Evans's syndrome-Lupus anticoagulant-Antiphospholipid-protein antibodies.

Clinical and Applied Thrombosis/Hemostasis, Vol. 3, No. 2, 96-98 (1997)
DOI: 10.1177/107602969700300204
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