|
Sign In to gain access to subscriptions and/or personal tools.
|
The Role of Adiponectin in Atherosclerosis and Thrombosis
Hakan Ekmekci, PhD
Istanbul University, Istanbul Medical Faculty, Department of Pediatric Haematology and Oncology, Bone Marrow Transplantation Unit
Ozlem B. Ekmekci, PhD
Istanbul University, Cerrahpasa Medical Faculty, Department of Biochemistry, Istanbul, Turkey
Obesity is a major risk factor for morbidity and mortality from cardiovascular causes. Adiponectin has been identified recently as one of the adipocytokines with important metabolic effects. It can suppress atherogenesis by inhibiting the adherence of monocytes, reducing their phagocytic activity, and suppressing the accumulation of modified lipoproteins in the vascular wall. In addition, as adiponectin decrease endothelial damage and stimulates production of NO from vascular endothelial cells, hypoadiponectinemia may be partially contribute to thrombus formation.
Key Words: Adiponectin • Atherosclerosis • Thrombosis
References
- Calle EC, Thun MJ, Petrelli JM, et al. Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med 1999;341:1097-1097.[Abstract/Free Full Text]
- Spiegelmen BM, Choy L, Hotamisligil GS, et al. Regulation of adipocyte gene expression in differentation and syndromes of obesity/diabetes. J Biol Chem 1993;268:6823-6823.[Free Full Text]
- Matsuzawa Y, Funahashi T, Nakamura T. Molecular mechanism of metabolic syndrome X: Contribution of adipocyte-derived bioactive substances. Ann NY Acad Sci 1999;892:146-146.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Friedman JM. Obesity in the new millenium. Nature 2000;404:632-632.[Medline]
[Order article via Infotrieve]
- Hotamisligil GS. The role of TNF-a and TNG receptors in obesity and insulin resistance. J Intern Med 1999;245:621-621.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Shimomura I, Funahashi T, Takahashi M, et al. Enhanced expression of PAI-1 in visceral fat. Possible contributor to vascular disease in obesity. Nat Med 1996;2:800-800.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- White RT, Damm D, Hancock N, et al. Human adipsin is identical to complement factor D and is expressed in high levels in adipose tissue. J Biol Chem 1992;267:9210-9210.[Abstract/Free Full Text]
- Steppan CM, Bailey ST, Bhat S, et al. The hormone resistin links obesity to diabetes. Nature 2001;409:307-307.[CrossRef][Medline]
[Order article via Infotrieve]
- Maeda K, Okubo K, Shimomura I, et al. cDNA clonning and expression of novel adipose specific collogen like factor apM1 (adipose most abundant gene transcript 1). Biochem Biophys Res Commun 1996;221:286-286.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Scherer PE, Williams S, Fogliano M, et al. A novel serum protein similar to C1q produced exclusively in adipocytes. J Biol Chem 1995;270:26746-26746.[Abstract/Free Full Text]
- Hu E, Liang P, Spiegelman BM. Adipo Q is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996;271:10697-10697.[Abstract/Free Full Text]
- Arita Y, Kihara S, Ouchi N, et al. Paradoxical decrease of an adipose-specific protein, adiponectin in obesity. Biochem Biophys Res Commun 1999;257:79-79.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Saito K, Tobe T, Minoshima S, et al. Organization of the gene for gelatin-binding protein (GBP 28). Gene 1999;229:67-67.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Takahashi M, Arita Y, Yamagata K, et al. Genomic structure and mutations in adipose-spesific gene, adiponectin. Int J Obes Relat Metab Disord 2000;24:861-861.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Yamauchi T, Kamon J, Ito Y, et al. Clonning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003;423:762-762.[CrossRef][Medline]
[Order article via Infotrieve]
- Berg AH, Combs TP, Scherer PE. Acrp 30/adiponectin: An adipocytokine regulating glucose and lipid metabolism. Trends Endocrinol Metab 2002;13:84-84.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Shimada K, Miyazaki T, Daida H. Adiponectin and atherosclerotic disease. Clin Chim Acta 2004;344:1-1.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Halleux CM, Takahashi M, Delporte MI, et al. Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissue. Biochem Biophys Res Commun 2001;288:1102-1102.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Moore GB, Chapman H, Holder JG, et al. Differential regulation of adipocytokine mRNAs by risiglitazone in db/db mice. Biochem Biophys Res Commun 2001;286:735-735.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Wang Y, Xu A, Knight C, et al. Hydroxylation and glycosylation of the four conserved ltsine residues in the collagenaus domain of adiponectin: Potential role in the modulation of its insulin-sensitizing activity. J Biol Chem 2002;277:19521-19521.[Abstract/Free Full Text]
- Sato L, Yasukawa Z, Honda N, et al. Identification and adipocyte differentiation-dependent expression of the unique disialic acid residue in an adipose tissue-specific glycoprotein adipoQ. J Biol Chem 2001;276:28849-28849.[Abstract/Free Full Text]
- Zoccali C, Mallamaci F, Tripepr G, et al. Adiponectin, metabolic risk factors, and cardiovascular events among patients with endstage renal disease. J Am Soc Nephrol 2002;13:134-134.[Abstract/Free Full Text]
- Chen H, Montagnani M, Funahashi T, et al. Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem 2003;278(45):45021-45021.[Abstract/Free Full Text]
- Chandran M, Ciaraldi T, Phillips SA, Henry RR. Adiponectin: More than just another fat cell hormone. Diabetes Care 2003;26(8):2442-2442.[Free Full Text]
- Ross R. The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature 1993;362:801-801.[CrossRef][Medline]
[Order article via Infotrieve]
- Arita Y, Kihara S, Ouchi N, et al. Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-vinding protein and regulates growth factor-induced common post receptor signal in vascular smooth muscle cell. Circulation 2002;18(105):2893-2893.
- Ouchi N, Kihara S, Funahashi T, et al. Reciprocal association of C-reactive protein with adiponectin in blood streams and adipose tissue. Circulation 2003;107:671-671.[Abstract/Free Full Text]
- Matsuda M, Shimomura I, Sata M, et al. Role of adiponectin in preventing vascular stenosis: The missing link of adipo-vascular axis. J Biol Chem 2002;277:37487-37487.[Abstract/Free Full Text]
- Vionet N, Hani El-H, Dupont S, et al. Genome wide search for type 2 diabetes susceptibility genes in french whites: Evidence for novel susceptibility locus for early onset diabetes on chromosome 3q27-q ter and independent replication of a type 2 diabetes locus on chromosome 1q21-q27. Am J Hum Genet 2000;67:1470-1470.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Okamoto Y, Arita Y, Nishida M, et al. An adipocyte-derived plasma protein, adiponectin, adheres to injures vascular walls. Horm Metab Res 2000;32:47-47.[Web of Science][Medline]
[Order article via Infotrieve]
- Ouchi N, Kihara S, Arita Y, et al. Novel modulator for endothelial adhesion molecules: Adipocyte-derived plasma protein adiponectin. Circulation 1999;100:2473-2473.[Abstract/Free Full Text]
- Ouchi N, Kihara S, Arita Y, et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappa B signalling yhrough a cAMP-dependent pathway. Circulation 2000;102:1296-1296.[Abstract/Free Full Text]
- Yamauchi T, Kamon J, Waki T, et al. The fat derived hormone adiponectin reserves insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001;7:941-941.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Kappes A, Loffler G. Influences of ionomycin, dibutyrylcycloAMP and tumor necrosis factor alpha on intracellular amount and secretion of apM1 in differentiating primary human preadipocytes. Hormone Metab Res 2000;32:548-548.[Web of Science][Medline]
[Order article via Infotrieve]
- Adamczak M, Wieck A, Funahashi T, et al. Decreased plasma adiponectin concentration in patients with essential hypertension. Am J Hypertens 2003;16:72-72.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Hotta K, Funahashi T, Arita Y, et al. Plasma concentration of a novel adipose spesific protein adiponectin in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 2000;20:1595-1595.[Abstract/Free Full Text]
- Kumada M, Kihara S, Sumitsuji S, et al. Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 2003;23:85-85.[Abstract/Free Full Text]
- Nakamuro Y, Shimada K, Fukuda D, et al. Implications of plasma concentrations of adiponectin in patients with coronary artery disease. Heart 2004;90(5):528-528.[Abstract/Free Full Text]
- Lakka HM, Laaksonen DE, Lakka TA, et al. The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 2002;288:2709-2709.[Abstract/Free Full Text]
- Lip GY, Edmunds E, Beevers DG. Should patients with hypertension receive antithrombotic therapy? J Intern Med 2001;249:205-205.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Gonzalez MA, Selwyn AP. Endothelial function, inflammation, and prognosis in cardiovascular disease. Am J Med 2003;115:99-99.[CrossRef]
- Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse longterm outcome of coronary heart disease. Circulation 2000; 101:1899-1899.[Abstract/Free Full Text]
- Ouchi N, Kihara S, Arita Y, et al. Adipocyte-derived plasma protein, adiponectin, suppresses lipid acumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation 2001;103:1057-1057.[Abstract/Free Full Text]
- Price DT, Loscalzo J. Cellular adhesion molecules and atherogenesis. Am J Med 1999;107:85-85.[Web of Science][Medline]
[Order article via Infotrieve]
- Radomski MW, Moncada S. Regulation of vascular homeostasis by nitric oxide. Thromb Haemost 1993;70:36-36.[Web of Science][Medline]
[Order article via Infotrieve]
- Riddell DR, Owen JS. Nitric oxide and platelet aggregation. Vitam Horm 1999;57:25-25.[Web of Science][Medline]
[Order article via Infotrieve]
- Sogo N, Magid KS, Shaw CA, et al. Inhibition of human platelet aggregation by nitric oxide donor drugs: Relative contribution of cGMP-independent mechanism. Biochem Biophys Res Commun 2000;279(2):412-412.[CrossRef][Web of Science][Medline]
[Order article via Infotrieve]
- Loscalzo J. Nitric oxide insufficiency, platelet activation, and arterial thrombosis. Circ Res 2001;88:756-756.[Abstract/Free Full Text]
Clinical and Applied Thrombosis/Hemostasis, Vol. 12, No. 2,
163-168 (2006)
DOI: 10.1177/107602960601200203
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter What's this?
This article has been cited by other articles:
|
|
|
|
 
C. Book, M. K. Karlsson, K. Akesson, and L. T. H. Jacobsson
Early rheumatoid arthritis and body composition
Rheumatology,
September 1, 2009;
48(9):
1128 - 1132.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Puglisi and M. L. Fernandez
Modulation of C-Reactive Protein, Tumor Necrosis Factor-{alpha}, and Adiponectin by Diet, Exercise, and Weight Loss
J. Nutr.,
December 1, 2008;
138(12):
2293 - 2296.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A H M van der Helm-van Mil, S M van der Kooij, C F Allaart, R E M Toes, and T W J Huizinga
A high body mass index has a protective effect on the amount of joint destruction in small joints in early rheumatoid arthritis
Ann Rheum Dis,
June 1, 2008;
67(6):
769 - 774.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Haugen and C. A. Drevon
Activation of Nuclear Factor-{kappa}B by High Molecular Weight and Globular Adiponectin
Endocrinology,
November 1, 2007;
148(11):
5478 - 5486.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
