This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (6) Citing Articles via Google Scholar Google Scholar Articles by Girolami, A. Articles by Bertolo, C. Search for Related Content PubMed PubMed Citation Articles by Girolami, A. Articles by Bertolo, C. Social Bookmarking                   What's this?

Myocardial Infarction and Arterial Thrombosis in Severe (Homozygous) FXII Deficiency: No Apparent Causative Relation

University of Padua Medical School, Department of Medical and Surgical Sciences, Second Chair of Medicine, Padua, Italy

M. Morello

University of Padua Medical School, Department of Medical and Surgical Sciences, Second Chair of Medicine, Padua, Italy

B. Girolami

University of Padua Medical School, Department of Medical and Surgical Sciences, Second Chair of Medicine, Padua, Italy

A. M. Lombardi

University of Padua Medical School, Department of Medical and Surgical Sciences, Second Chair of Medicine, Padua, Italy

C. Bertolo

University of Padua Medical School, Department of Medical and Surgical Sciences, Second Chair of Medicine, Padua, Italy

Twenty-one patients (12 female and 9 male) with severe (homozygous) factor XII (FXII) deficiency and 58 (32 female and 26 male) with heterozygous FXII deficiency were observed for an average 16.2 years. No patient with homozygous FXII deficiency experienced myocardial infarction or any other arterial thrombosis. The same was true for heterozygotes. The cases of FXII deficiency and arterial thrombosis reported in the literature were evaluated. In every instance, associated risk factors were present that could justify the arterial thrombosis. Dyslipidemia, hypertension, smoking, and diabetes mellitus were the most frequent findings. The examination of the few papers that dealt with the prevalence of arterial thrombosis in patients with severe FXII deficiency showed that only 1 patient of 61 experienced myocardial infarction. In conclusion, it seems that the role of FXII deficiency in the pathogenesis of arterial thrombosis is minor.

Key Words: Coagulation • Arterial thrombosis • Factor XII deficiency • Contact phase

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				A. Sotiriadis, A. Makrigiannakis, T. Stefos, E. Paraskevaidis, and S. N. Kalantaridou Fibrinolytic Defects and Recurrent Miscarriage: A Systematic Review and Meta-Analysis Obstet. Gynecol., May 1, 2007; 109(5): 1146 - 1155. [Abstract] [Full Text] [PDF]

				C. Kleinschnitz, G. Stoll, M. Bendszus, K. Schuh, H.-U. Pauer, P. Burfeind, C. Renne, D. Gailani, B. Nieswandt, and T. Renne Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis J. Exp. Med., March 20, 2006; 203(3): 513 - 518. [Abstract] [Full Text] [PDF]

				T. Renne, M. Pozgajova, S. Gruner, K. Schuh, H.-U. Pauer, P. Burfeind, D. Gailani, and B. Nieswandt Defective thrombus formation in mice lacking coagulation factor XII J. Exp. Med., July 18, 2005; 202(2): 271 - 281. [Abstract] [Full Text] [PDF]