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This version was published on July 1, 2008
Clinical and Applied Thrombosis/Hemostasis, Vol. 14, No. 3, 338-345 (2008)
DOI: 10.1177/1076029607305083

Adipokines, Linking Adipocytes and Vascular Function in Hemodialyzed Patients, May Also Be Possibly Related to CD146, a Novel Adhesion Molecule

J. Malyszko, MD, PhD

Department of Nephrology and Transplantology, Medical University, Bialystok, jolmal{at}poczta.onet.pl

J.S. Malyszko, MD, PhD

Department of Nephrology and Transplantology, Medical University, Bialystok

P. Kozminski, MD, PhD

Dialysis Unit, Regional Hospital Dzialdowo, Poland

K. Pawlak, MD, PhD

Department of Nephrology and Transplantology, Medical University, Bialystok

M. Mysliwiec, MD, PhD

Department of Nephrology and Transplantology, Medical University, Bialystok

Possible correlations between adiponectin, leptin, CD146, a novel adhesion molecule localized at the endothelial junction, and other markers of endothelial cell injury, von Willebrand factor, thrombomodulin, vascular cell adhesion molecule, and intracellular adhesion molecule, and markers of inflammation, tumor necrosis factor-{alpha}, interleukin-6, and high-sensitivity C-reactive protein in nondiabetic hemodialyzed patients with and without coronary artery disease were studied. Markers of endothelial dysfunction were elevated in hemodialyzed patients, predominantly with coronary artery disease. In multivariate analysis, kinetic urea modeling and plasminogen activator inhibitor-1 remained the only positive predictors of adiponectin. In multivariate analysis, predictors of leptin were triglycerides, tissue plasminogen activator, CD146, and coronary artery disease. In multivariate analysis, predictors of CD146 were age, hemoglobin, and adiponectin. Elevated adiponectin correlated to CD146 may be the expression of a counterregulatory response aimed at mitigating the consequences in endothelial damage and increased cardiovascular risk in renal failure. The data provide further support for a link between adipocytokines, endothelial dysfunction, cardiovascular risk, and renal failure.

Key Words: adiponectin • CD146 • HD • leptin • endothelium • adhesion molecules


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