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This version was published on July 1, 2008
Clinical and Applied Thrombosis/Hemostasis, Vol. 14, No. 3, 346-351 (2008)
DOI: 10.1177/1076029607306397

Platelet Aggregation and Activation in Thalassemia Major Patients in Indonesia

Rahajuningsih Setiabudy, MD, DSc

Department of Clinical Pathology, University of Indonesia, setiabudy{at}cbn.net.id

Pustika Amalia Wahidiyat, MD

Department of Child Health, Hematology Subdivision, Thalassemia Center Ciptomangunkusumo National General Hospital, University of Indonesia, Jakarta

Lyana Setiawan, MD

Department of Clinical Pathology, University of Indonesia

Thromboembolic events and hypercoagulable state have been reported in patients with thalassemia. As platelets play an important role in the pathogenesis of thrombosis, the authors aimed to find the pattern of changes in platelet count, function and activation, and evidence of coagulation activation in patients with thalassemia major in Indonesia. A total of 31 patients with splenectomized and 35 patients with nonsplenectomized thalassemia major were enrolled in this study. Platelet count, platelet aggregation, β-thromboglobulin, and D-dimer levels were measured. All measured parameters were significantly higher in splenectomized than in nonsplenectomized patients. β-thromboglobulin level was increased, but D-dimer level was within normal range. The authors concluded that there was an increase in platelet activation in patients with β-thalassemia major. Platelet activation was higher in splenectomized than in nonsplenectomized patients.

Key Words: platelet aggregation • platelet activation • βthromboglobulin • thalassemia major • β-thalassemia/HbE


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