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The Antiphospholipid Thrombosis Syndromes: A Common Multidisciplinary Medical Problem

Clinical Professor of Medicine and Pathology; University of Texas Southwestern Medical Center and Director of the Dallas Thrombosis Hemostasis and Hematology Clinical Center Dallas, Texas, U.S.A.

Antiphospholipid antibodies are increasingly being identified as a cause of arterial and venous thrombosis as well as fetal wastage syndrome via placental vascular thrombosis. The antiphospholipid thrombosis syndromes should be considered and searched for when suggestive clinical findings are present or when unexplained arterial or venous thrombosis occurs. Noting the presence and type of antiphospholipid antibody thrombosis syndrome assumes major importance with respect to not only making an accurate diagnosis of cause of thrombosis but also in selecting effective antithrombotic therapy. The antiphospholipid thrombosis syndromes and the thrombotic and other clinical manifestations span almost all medical specialities and should be construed as a truly multidisciptinary medical problem. Key Words: Thrombosis-Anticardiolipin antibody—Lupus anticoagulant.

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