This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Girolami, A. Articles by Luni, S. Search for Related Content PubMed Articles by Girolami, A. Articles by Luni, S. Social Bookmarking                   What's this?

Asymptomatic Homozygous nt 20210 G to A Prothrombin Polymorphism in Two Blood Donors Belonging to Two Different Kindreds

University of Padua Medical School. Institute of Medical Semeiotics and Second Chair of Medicine, Padua, Italy

Paolo Simioni

University of Padua Medical School. Institute of Medical Semeiotics and Second Chair of Medicine, Padua, Italy

Davide Manfrin

University of Padua Medical School. Institute of Medical Semeiotics and Second Chair of Medicine, Padua, Italy

Daniela Tormene

University of Padua Medical School. Institute of Medical Semeiotics and Second Chair of Medicine, Padua, Italy

Sonia Luni

University of Padua Medical School. Institute of Medical Semeiotics and Second Chair of Medicine, Padua, Italy

The nucleotide (nt) 20210 G to A prothrombin polymorphism has been associated with an increased incidence of thrombosis, particularly venous thrombosis. The increased incidence of thrombosis resulted from an increase in prothrom bin levels. Two homozygous patients with this abnormality were found to be completely asymptomatic. In one of the two cases there was no thrombosis even after the additional risk factor of oral contraceptive therapy for several months. Pro thrombin activity and antigen as assayed by several methods were at the upper limits of normalcy in one case and slightly elevated in the other. The two cases described in this article do not rule out the possibility that this prothrombin abnormality be associated, given special acquired circumstances, with throm bosis. However, they indicate that extreme caution is needed to avoid an inaccurate conclusion. The fact that homozygous pa tients may remain asymptomatic indicates that the prothrom botic defect is very mild, if any. Key Words: Prothrombin— 20210 G to A abnormality—Thrombosis—Polymorphism.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				D. Bosler, J. Mattson, and D. Crisan Phenotypic Heterogeneity in Patients with Homozygous Prothrombin 20210AA Genotype: A Paper from the 2005 William Beaumont Hospital Symposium on Molecular Pathology J. Mol. Diagn., September 1, 2006; 8(4): 420 - 425. [Abstract] [Full Text] [PDF]

				V. Cobankara, B. Oran, D. Ozatli, I. C. Haznedaroglu, A. Kosar, Y. Buyukasik, O. Ozcebe, S. Dundar, and S. Kirazli Cytokines, Endothelium, and Adhesive Molecules in Pathologic Thrombopoiesis Clinical and Applied Thrombosis/Hemostasis, April 1, 2001; 7(2): 126 - 130. [Abstract] [PDF]

				A. Girolami and F. Vianello The Significance or Nonsignificance of the G to A 20210 Prothrombin Polymorphism Clinical and Applied Thrombosis/Hemostasis, October 1, 2000; 6(4): 239 - 240. [PDF]

				A. Girolami, P. Simioni, B. Girolami, and L. Scarano State-of-the-Art Review : G to A 20210 Prothrombin Polymorphism and Venous Thrombosis: Simple Association or Causal Relationship? Clinical and Applied Thrombosis/Hemostasis, July 1, 2000; 6(3): 135 - 138. [PDF]

				A. Girolami, P. Simioni, B. Girolami, and E. Zanon State-of-the-Art Review: Low Incidence of Venous Thrombosis in Homozygous Patients with NT 20210 G to a Prothrombin Polymorphism Clinical and Applied Thrombosis/Hemostasis, October 1, 1999; 5(4): 205 - 207. [PDF]

				N. Akar and Y. Egin A Further Case of Homozygous G20210A Prothrombin Gene Mutation Without Thromboembolic Events Clinical and Applied Thrombosis/Hemostasis, October 1, 1999; 5(4): 284 - 284. [PDF]